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Study of Synthetic Oligonacleotides Containing Guanine by Voltammetry on a Graphite Electrode

  1. 1.
    0506554 - BFU-R 2020 RIV CZ eng C - Konferenční příspěvek (zahraniční konf.)
    Hejduková, M. - Špaček, Jan - Fojta, Miroslav - Havran, L. - Renciuk, D.
    Study of Synthetic Oligonacleotides Containing Guanine by Voltammetry on a Graphite Electrode.
    XXXVIII. Moderní elektrochemické metody. Sborník přednášek. Ústí nad Labem: Best Servis, 2018 - (Navrátil, T.; Fojta, M.; Schwarzová, K.), Č. 2018 (2018), s. 74-76. ISBN 978-80-905221-6-9.
    [Moderní elektrochemické metody /38./. Jetřichovice (CZ), 21.05.2018-25.05.2018]
    Grant CEP: GA ČR(CZ) GA16-01625S; GA MŠk EF15_003/0000477
    Institucionální podpora: RVO:68081707
    Klíčová slova: Oligonucleotides * Pyrolytic graphite electrode * Linear sweep voltammetry
    Kód oboru RIV: CF - Fyzikální chemie a teoretická chemie
    Obor OECD: Physical chemistry

    Electrochemical oxidation of specifically designed DNA hexamers containing guanine has been studied in aqueous acetate buffet (pH 5) at a pyrolytic graphite electrode (PGE) by linear sweep voltammetry (LSV) Influence of the oligonucleotide composition and concentration was investigated It seems that short oligonucleotides containing guanine produce oxidation signals. which are sensitive to their structural properties Simple electrochemical techniques us may be useful tool for monitoring of structural changes of DNA.
    Trvalý link: http://hdl.handle.net/11104/0297787