Plasma TIMP1 Level Is a Prognostic Factor in Patients with Liver Metastases

0505368 - ÚI 2020 GR eng J - Článek v odborném periodiku
Buňátová, K. - Pešta, M. - Kulda, V. - Topolčan, O. - Vrzalová, J. - Sutnar, A. - Třeška, V. - Pecen, Ladislav - Liška, V.
Plasma TIMP1 Level Is a Prognostic Factor in Patients with Liver Metastases.
Anticancer Research. Roč. 32, č. 10 (2012), s. 4601-4606. ISSN 0250-7005. E-ISSN 1791-7530
Klíčová slova: primary colorectal-cancer * tissue inhibitor * matrix metalloproteinase-1 * clinical-relevance * hepatic resection * serum * survival * mmp-9 * cea * combination * Tumor markers * liver metastases * timp1 * prognosis * blood plasma
Impakt faktor: 1.713, rok: 2012

TIMP1 (tissue inhibitor of metalloproteinases 1) regulates extracellular matrix turnover and also promotes cell growth and has anti-apoptotic activity, which promotes malignant processes in tumor tissue. The aim of our study was to evaluate the relation of plasma TIMP I protein levels with prognosis in patients with liver metastases, with particular regard to possible early-prediction of recurrence of the disease. Patients and Methods: We studied a group of 87 patients with metastatic liver disease (mostly from colorectal cancer) who underwent surgery for liver metastases, and assessed their preoperative plasma TIMP1 levels. These levels were evaluated according to prognosis. Furthermore, we measured plasma TIMP1 in the postoperative period and tried to relate the changes with the diagnosis of relapse. Results: We found preoperative plasma TIMP I levels to be related to overall survival in the group of all patients with metastatic liver disease (p=0.0047), with a higher level being associated with an adverse outcome; the cut-off value was set at 165 ng/ml. This applied to all patients, regardless of the type of surgery. Assessment of the post-operative dynamics of TIMP1 was not found to be statistically significant to indicate disease recurrence. Conclusion: We found there to be a relationship between higher plasma levels of TIMP1 and an adverse prognosis in patients with liver metastases. The assessment of plasma TIMP1 levels could help the detection of patients with worse outcome.
Trvalý link: http://hdl.handle.net/11104/0296814