Počet záznamů: 1  

Loss of neuronal network resilience precedes seizures and determines the ictogenic nature of interictal synaptic perturbations

  1. 1.
    0498725 - FGÚ 2019 RIV US eng J - Článek v odborném periodiku
    Chang, W.C. - Kudláček, Jan - Hlinka, Jaroslav - Chvojka, Jan - Hadrava, Michal - Kumpošt, Vojtěch - Powell, A. D. - Janča, R. - Maturana, M. I. - Karoly, P. J. - Freestone, D. R. - Cook, M. J. - Paluš, Milan - Otáhal, Jakub - Jefferys, J. G. R. - Jiruška, Přemysl
    Loss of neuronal network resilience precedes seizures and determines the ictogenic nature of interictal synaptic perturbations.
    Nature Neuroscience. Roč. 21, č. 12 (2018), s. 1742-1752. ISSN 1097-6256
    Grant CEP: GA ČR(CZ) GA14-02634S; GA MZd(CZ) NV15-29835A; GA MZd(CZ) NV17-28427A
    Institucionální podpora: RVO:67985823 ; RVO:67985807
    Klíčová slova: seizures * dynamics * perturbations * transition to seizure * critical slowing * catastrophic shifts * high-frequency activity * interictal epileptiform discharges
    Kód oboru RIV: FH - Neurologie, neurochirurgie, neurovědy
    Obor OECD: Neurosciences (including psychophysiology
    Impakt faktor: 21.126, rok: 2018

    The mechanism of seizure emergence and the role of brief interictal epileptiform discharges (IEDs) in seizure generation are two of the most important unresolved issues in modern epilepsy research. We found that the transition to seizure is not a sudden phenomenon, but is instead a slow process that is characterized by the progressive loss of neuronal network resilience. From a dynamical perspective, the slow transition is governed by the principles of critical slowing, a robust natural phenomenon that is observable in systems characterized by transitions between dynamical regimes. In epilepsy, this process is modulated by synchronous synaptic input from IEDs. IEDs are external perturbations that produce phasic changes in the slow transition process and exert opposing effects on the dynamics of a seizure-generating network, causing either anti-seizure or pro-seizure effects. We found that the multifaceted nature of IEDs is defined by the dynamical state of the network at the moment of the discharge occurrence.
    Trvalý link: http://hdl.handle.net/11104/0291007