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Detection of chloroalkanes by surface-enhanced raman spectroscopy in microfluidic chips

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    0494591 - ÚPT 2019 RIV CH eng J - Článek v odborném periodiku
    Pilát, Zdeněk - Kizovský, Martin - Ježek, Jan - Krátký, Stanislav - Sobota, Jaroslav - Šiler, Martin - Samek, Ota - Buryška, T. - Vaňáček, P. - Damborský, J. - Prokop, Z. - Zemánek, Pavel
    Detection of chloroalkanes by surface-enhanced raman spectroscopy in microfluidic chips.
    Sensors. Roč. 18, č. 10 (2018), č. článku 3212. E-ISSN 1424-8220
    Grant CEP: GA ČR(CZ) GA16-07965S; GA MŠk(CZ) LO1212; GA MŠk ED0017/01/01
    Institucionální podpora: RVO:68081731
    Klíčová slova: surface enhanced raman spectroscopy * microfluidics * Klarite 312 * chloroalkane * 1,2,3-trichloropropane
    Kód oboru RIV: BH - Optika, masery a lasery
    Obor OECD: Optics (including laser optics and quantum optics)
    Impakt faktor: 3.031, rok: 2018

    Optofluidics, a research discipline combining optics with microfluidics, currently aspires to revolutionize the analysis of biological and chemical samples, e.g., for medicine, pharmacology, or molecular biology. In order to detect low concentrations of analytes in water, we have developed an optofluidic device containing a nanostructured substrate for surface enhanced Raman spectroscopy (SERS). The geometry of the gold surface allows localized plasmon oscillations to give rise to the SERS effect, in which the Raman spectral lines are intensified by the interaction of the plasmonic field with the electrons in the molecular bonds. The SERS substrate was enclosed in a microfluidic system, which allowed transport and precise mixing of the analyzed fluids, while preventing contamination or abrasion of the highly sensitive substrate. To illustrate its practical use, we employed the device for quantitative detection of persistent environmental pollutant 1,2,3-trichloropropane in water in submillimolar concentrations. The developed sensor allows fast and simple quantification of halogenated compounds and it will contribute towards the environmental monitoring and enzymology experiments with engineered haloalkane dehalogenase enzymes.
    Trvalý link: http://hdl.handle.net/11104/0287701
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