Racemic Mixture Separation with Chiral Polymeric Membranes.

0490481 - ÚCHP 2019 BR eng C - Konferenční příspěvek (zahraniční konf.)
Gaálová, Jana - Stibor, Ivan - Cuřínová, Petra - Žitka, Jan - Brožová, Libuše - Otmar, Miroslav - Sysel, P. - Hovorka, Š. - Izák, Pavel
Racemic Mixture Separation with Chiral Polymeric Membranes.
Book of Abstracts. -: -, 2018 - (Ban, M.), s. 209. ISBN N. ISSN 1847-7186.
[Latin American Conference on Sustainable Development of Energy, Water and Environmental Systems /1./. Rio de Janeiro (BR), 28.01.2018-31.01.2018]
Grant CEP: GA ČR(CZ) GA17-00089S
Institucionální podpora: RVO:67985858 ; RVO:61389013
Klíčová slova: chiral polymeric membrane * pharmaceutical industry * pervaporation experiments
Obor OECD: Chemical process engineering; Polymer science (UMCH-V)

Drug stereochemistry has become an issue for the pharmaceutical industry and the regulatory authorities, because each of the enantiomers frequently shows different impacts to living organisms. The goal of the proposal is to develop new membrane separation techniques for successful resolution of racemic mixtures allowing optimization of the therapeutic value of enantiomeric drugs (pharmacological and toxicological) and avoiding their adverse effects. The key objective is to separate enantiomers by a new membrane separation method, based on the proposed “supported chiral room temperature ionic liquid membrane”, that has never been studied yet. In comparison with classical methods employed earlier, it should show higher efficiency and cost-effectiveness in the processes of enantiomer separation. To greatly reduce the amount of experimental work, particle-based modeling will be employed. After gathering all transport characteristics, it will be possible to model the separation process and to estimate
permeability and selectivity of the separation.
Trvalý link: http://hdl.handle.net/11104/0284710