0488816 - MBÚ 2019 RIV GB eng J - Článek v odborném periodiku
Škríba, Anton - Havlíček, Vladimír
Mass spectrometry imaging of illicit drugs in latent fingerprints by matrix-free and matrix-assisted desorption/ionization techniques.
European Journal of Mass Spectrometry. Roč. 24, č. 1 (2018), s. 124-128. ISSN 1469-0667
Grant CEP: GA MŠMT(CZ) LO1509; GA ČR(CZ) GA16-20229S
Institucionální podpora: RVO:61388971
Klíčová slova: MALDI * Mass spectrometry imaging * NALDI
Obor OECD: Analytical chemistry
Impakt faktor: 0.851, rok: 2018 ; AIS: 0.242, rok: 2018
DOI: https://doi.org/10.1177/1469066717728007

Compared with classical matrix-assisted laser-desorption ionization mass spectrometry (MALDI), the matrix free-based strategies generate a cleaner background, without significant noise or interference coming from an applied matrix, which is beneficial for the analysis of small molecules, such as drugs of abuse. In this work, we probed the detection efficiency of methamphetamine, heroin and cocaine in nanostructure-assisted laser desorption-ionization (NALDI) and desorption electrospray ionization and compared the sensitivity of these two matrix-free tools with a standard MALDI mass spectrometry experiment. In a typical mass spectrometry imaging (MSI) setup, papillary line latent fingerprints were recorded as a mixture a common skin fatty acid or interfering cosmetics with a drug. In a separate experiment, all drugs (1 µL of 1 μM standard solution) were detected by all three ionization techniques on a target. In the case of cocaine and heroin, NALDI mass spectrometry was the most sensitive and revealed signals even from 0.1 μM solution. The drug/drug contaminant (fatty acid or cosmetics) MSI approach could be used by law enforcement personnel to confirm drug abusers of having come into contact with the suspected drug by use of fingerprint scans at time of apprehension which can aid in reducing the work of lab officials.
Trvalý link: http://hdl.handle.net/11104/0283656