The rs1527483, but not rs3212018, CD36 polymorphism associates with linoleic acid detection and obesity in Czech young adults

0488578 - ÚŽFG 2019 RIV GB eng J - Článek v odborném periodiku
Plesník, J. - Šerý, Omar - Khan, A. S. - Bielik, P. - Khan, N. A.
The rs1527483, but not rs3212018, CD36 polymorphism associates with linoleic acid detection and obesity in Czech young adults.
British Journal of Nutrition. Roč. 119, č. 4 (2018), s. 472-478. ISSN 0007-1145. E-ISSN 1475-2662
Grant CEP: GA MZd(CZ) NV16-29900A
Institucionální podpora: RVO:67985904
Klíčová slova: CD36 * fat taste * genetic polymorphism * rs1527483
Obor OECD: Physiology (including cytology)
Impakt faktor: 3.319, rok: 2018

Recent evidence has raised the possibility of the existence of a sixth taste modality - that is, taste for fat - which is mediated by lingual CD36 and plays a role in obesity. Consequently, the genetic polymorphism of CD36 has been shown to be associated with altered oro-sensory detection of dietary lipids. In the present study, we investigated the relationship between oro-sensory perception of linoleic acid (LA), two CD36 polymorphisms (rs1527483 and rs3212018), obesity parameters and craving habits for dietary lipids in young Czech adults. We also sequenced 5 and 6 exons of CD36 to trace out any new mutation that might be responsible for the difference in taste perception. We observed that craving for dietary lipids was correlated with anthropometric parameters (P<0.05) and LA detection threshold (P=0.033). The participants with the CC genotype of the rs1527483 polymorphism had lower BMI (P=0.011), waist circumference (P=0.005), waist:height ratio (P=0.010) and higher sensitivity for LA (P=0.037) than the participants with the CT and TT genotypes. Interestingly, we did not observe any association between the rs3212018 polymorphism and the studied parameters. Moreover, we did not observe any mutation in exons 5 and 6 of the CD36 gene in these subjects. Finally, we can state that rs1527483, but not rs3212018, is associated with high body weight in young Czech subjects.
Trvalý link: http://hdl.handle.net/11104/0283151