Designing Porphyrinic Covalent Organic Frameworks for the Photodynamic Inactivation of Bacteria

0488571 - ÚACH 2019 RIV US eng J - Článek v odborném periodiku
Hynek, Jan - Zelenka, J. - Rathouský, Jiří - Kubát, Pavel - Ruml, T. - Demel, Jan - Lang, Kamil
Designing Porphyrinic Covalent Organic Frameworks for the Photodynamic Inactivation of Bacteria.
ACS Applied Materials and Interfaces. Roč. 10, č. 10 (2018), s. 8527-8535. ISSN 1944-8244. E-ISSN 1944-8252
Grant CEP: GA ČR(CZ) GA16-15020S
Institucionální podpora: RVO:61388980 ; RVO:61388955
Klíčová slova: antibacterial coating * biofilm * covalent organic framework * photodynamic * porphyrin * singlet oxygen
Obor OECD: Inorganic and nuclear chemistry; Physical chemistry (UFCH-W)
Impakt faktor: 8.456, rok: 2018

Microbial colonization of biomedical devices is a recognized complication contributing to healthcare-associated infections. One of the possible approaches to prevent surfaces from the biofilm formation is antimicrobial photodynamic inactivation based on the cytotoxic effect of singlet oxygen, O 2 ( 1 Δ g ), a short-lived, highly oxidative species, produced by energy transfer between excited photosensitizers and molecular oxygen. We synthesized porphyrin-based covalent organic frameworks (COFs) by Schiff-base chemistry. These novel COFs have a three-dimensional, diamond-like structure. The detailed analysis of their photophysical and photochemical properties shows that the COFs effectively produce O 2 ( 1 Δ g ) under visible light irradiation, and especially three-dimensional structures have strong antibacterial effects toward Pseudomonas aeruginosa and Enterococcus faecalis biofilms. The COFs exhibit high photostability and broad spectral efficiency. Hence, the porphyrinic COFs are suitable candidates for the design of antibacterial coating for indoor applications.
Trvalý link: http://hdl.handle.net/11104/0283142


Vědecká data: ACS publications