Počet záznamů: 1  

Proton irradiation: a key to the challenge of N-glycosidic bond formation in a prebiotic context

  1. 1.
    0486060 - BFÚ 2018 RIV GB eng J - Článek v odborném periodiku
    Saladino, R. - Bizzarri, B.M. - Botta, L. - Šponer, Jiří - Šponer, Judit E. - Georgelin, T. - Jaber, M. - Rigaud, B. - Kapralov, M. - Timoshenko, G. N. - Rozanov, A. - Krasavin, E. - Timperio, A.M. - Di Mauro, E.
    Proton irradiation: a key to the challenge of N-glycosidic bond formation in a prebiotic context.
    Scientific Reports. Roč. 7, NOV2017 (2017), č. článku 14709. ISSN 2045-2322. E-ISSN 2045-2322
    Grant CEP: GA ČR GA17-05076S
    Institucionální podpora: RVO:68081707
    Klíčová slova: aqueous-solution * nucleic-acids * formamide * radicals
    Obor OECD: Biochemistry and molecular biology
    Impakt faktor: 4.122, rok: 2017

    The formation of nucleosides in abiotic conditions is a major hurdle in origin-of-life studies. We have determined the pathway of a general reaction leading to the one-pot synthesis of ribo-and 2 '-deoxyribonucleosides from sugars and purine nucleobases under proton irradiation in the presence of a chondrite meteorite. These conditions simulate the presumptive conditions in space or on an early Earth fluxed by slow protons from the solar wind, potentially mimicking a plausible prebiotic scenario. The reaction (i) requires neither pre-activated precursors nor intermediate purification/concentration steps, (ii) is based on a defined radical mechanism, and (iii) is characterized by stereoselectivity, regioselectivity and (poly) glycosylation. The yield is enhanced by formamide and meteorite relative to the control reaction.
    Trvalý link: http://hdl.handle.net/11104/0280947

     
     
Počet záznamů: 1  

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