0485405 - ÚFCH JH 2019 RIV US eng J - Článek v odborném periodiku
Pelclová, D. - Urban, P. - Fenclová, Z. - Vlčková, Š. - Ridzoň, P. - Kupka, K. - Mecková, Z. - Bezdíček, O. - Navrátil, Tomáš - Rosmus, J. - Zakharov, S.
Neurological and Neurophysiological Findings in Workers with Chronic 2,3,7,8-Tetrachlorodibenzo-p-Dioxin Intoxication 50 Years After Exposure.
Basic & Clinical Pharmacology & Toxicology. Roč. 122, č. 2 (2018), s. 271-277. ISSN 1742-7835. E-ISSN 1742-7843
Institucionální podpora: RVO:61388955
Klíčová slova: neurological findings * intoxication * TCDD
Obor OECD: Physical chemistry
Impakt faktor: 2.452, rok: 2018 ; AIS: 0.629, rok: 2018
DOI: https://doi.org/10.1111/bcpt.12899

The last eight survivors of 80 workers accidentally exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) during production
of herbicides based on trichlorophenoxyacetic acid in 1965–1967 in a chemical factory were followed. All were men,
mean age 72.4 +- 1.3 years. Their current median TCDD blood level was 112 (46–390) pg/g lipids. Neurological examination
revealed central nervous system impairment in all individuals and signs of polyneuropathy in 87.5%, which was confirmed by a
nerve conduction study (NCS) in 75%. A Lanthony test demonstrated acquired dyschromatopsia in 87.5% of the patients, with
deterioration of mean colour confusion index (CCI) from 1.52 +- 0.39 in 2010 to 1.73 +- 0.41 in 2016. Single-photon emission
computer tomography (SPECT) of the brain showed focal reduction of perfusion in various brain locations in all patients and
worsening in six patients. Visual-evoked potentials (VEP) was abnormal in 62.6% of individuals. Most patients complained of
psychological problems. The neuropsychological test battery showed most positive impairments in the Trail Making Test evaluating
processing speed (average level in the range of mild neurocognitive impairment), which correlated with mean CCI
(p < 0.05). Conclusion: Fifty years after exposure, blood levels of TCDD are still 10 times higher than the general population.
NCS, VEP, Lanthony test and SPECT findings deteriorated from examination of these patients in 2004 and in 2010. The total of
abnormal tests per patient in 2016 is very high. Minor differences among patients and their reduced count may explain why the
number of impairments in 2016 does not correlate with TCDD blood level.
Trvalý link: http://hdl.handle.net/11104/0280433