Počet záznamů: 1  

Potential markers for early diagnostics of Colorectal cancer and Inflammatory bowel disease in humans : intestinal microorganisms and immune system (teammates or rivals)

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    0483861 - ÚŽFG 2018 RIV CA eng J - Článek v odborném periodiku
    Horák, P. - Kučerová, Petra - Červinková, Monika
    Potential markers for early diagnostics of Colorectal cancer and Inflammatory bowel disease in humans : intestinal microorganisms and immune system (teammates or rivals).
    Canadian Journal of Biotechnology. Roč. 1, č. 2 (2017), s. 59-64. E-ISSN 2560-8304
    Grant CEP: GA MŠMT(CZ) LO1609
    Institucionální podpora: RVO:67985904
    Klíčová slova: colorectal cancer * inflammatory bowel disease * immune markers
    Obor OECD: Immunology

    Chronic inflammation of the bowel is the characteristic of Inflammatory bowel diseases including Ulcerative colitis and Crohn’s disease. The incidence of Inflammatory bowel disease (IBD) in Western Europe is 14/100,000 of inhabitants. Duration and severity of inflammation increases the risk of Colorectal cancer (CRC) development by about 60% in IBD patients. CRC is the 3rd most common type of tumor in Western population. Every year, more than one million new cases are diagnosed with more than 600,000 deaths.
    The early detection of CRC, originating from any part of the colon-rectum, is desirable because it can be cured surgically if diagnosed timely. Identification of new early markers for IBD and CRC is very important.
    This review deals with the searching and identification of possibly new early markers for the above mentioned pathologies. We have focused on intestinal microorganisms (changes in qualitative and quantitative composition of microbiome, selection of candidate microorganisms) and immune system markers (cytokines, chemokines, nuclear factor kB, Toll-like receptors and Receptor for Advanced Glycation End Products).
    Trvalý link: http://hdl.handle.net/11104/0279023

     
     
Počet záznamů: 1  

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