0482212 - ÚEM 2018 RIV GB eng J - Článek v odborném periodiku
Zölzer, F. - Křížová, M. - Skalická, Z.F. - Rössnerová, Andrea - Šrám, Radim
Micronucleus frequency and content in healthy relatives of cancer patients.
Biomarkers. Roč. 22, č. 7 (2017), s. 667-673. ISSN 1354-750X. E-ISSN 1366-5804
Institucionální podpora: RVO:68378041
Klíčová slova: micronucleus centromere test * chromosomal damage * inheritable trait
Obor OECD: Human genetics
Impakt faktor: 1.976, rok: 2017 ; AIS: 0.516, rok: 2017
DOI: https://doi.org/10.1080/1354750X.2016.1276627

Objective: To compare chromosomal damage in lymphocytes of individuals who did or did not report first-degree relatives with cancer.

Materials and methods: Cases and controls (68 each) were matched for sex, age and radon exposure. Chromosomal damage was quantified as frequency of micronucleus-containing cells and proportion of centromere-free micronuclei.

Results: Individuals not reporting cancer in their families showed lower values of both the frequency of micronucleus-containing cells (n.s.) and the proportion of centromere-free micronuclei (p<0.05) in some subgroups, but not in all.

Conclusion: The chromosomal damage observed may be due to inheritable genomic instability, but environmental influences cannot be excluded.
Trvalý link: http://hdl.handle.net/11104/0277610