Počet záznamů: 1  

Mimicking of cyproconazole behavior in the presence of Cu and Zn

  1. 1.
    0481808 - ÚOCHB 2018 RIV GB eng J - Článek v odborném periodiku
    Jakl, M. - Fanfrlík, Jindřich - Jaklová Dytrtová, Jana
    Mimicking of cyproconazole behavior in the presence of Cu and Zn.
    Rapid Communications in Mass Spectrometry. Roč. 31, č. 23 (2017), s. 2043-2050. ISSN 0951-4198. E-ISSN 1097-0231
    Grant CEP: GA ČR GP13-21409P
    Institucionální podpora: RVO:61388963
    Klíčová slova: triazole fungicides * azole fungicides * copper
    Obor OECD: Analytical chemistry
    Impakt faktor: 1.970, rok: 2017

    The frequently used pesticide cyproconazole (Cyp) interacts with the essential elements commonly present in soil which play important roles in various enzymatic processes. These interactions predetermine the Cyp degradation pathways. We suggest a simple experimental and theoretical approach for the prediction of pesticide behavior. Cu/Cyp complexes are explored because of the typical Cu(II) reduction in complexes. Its level and the stability of the Cu-ligand bond depend on the type and the number of the surrounding ligands. Zn/Cyp complexes were compared as it is not expected that Zn(II) will reduce. The complexations were studied by means of electrospray ionization ion trap mass spectrometry and MS/MS collision-induced dissociations with comparative and explicative density functional theory calculations. The Cyp ligand allows both Cu(II) reduction as well as, in specific cases, it protects the higher Cu oxidation state. The reduction is observed in the complexes with solely neutral Cyp where the number of ligands is below 3, a higher number protects the Cu(II) state. The metal atom binds to Cyp via N2 of the triazole ring as well as via -electrons of the benzene ring, additional stabilization brings an interaction with the deprotonated OH group. The character of Cyp interactions with doubly charged metals (Cu(II), Zn(II)) clarified the creation of Cyp metabolites. The phenyl and triazole rings are bound to the metal cation and enable access for the isopropyl ring to be cleaved leaving the common metabolite (CAS Number: 58905-19-4).
    Trvalý link: http://hdl.handle.net/11104/0277461

     
     
Počet záznamů: 1  

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