Počet záznamů: 1  

Genome Compositional Organization in Gars Shows More Similarities to Mammals than to Other Ray-Finned Fish

  1. 1.
    0481774 - ÚŽFG 2018 RIV US eng J - Článek v odborném periodiku
    Symonová, Radka - Majtánová, Zuzana - Arias-Rodriquez, L. - Mořkovský, L. - Kořínková, Tereza - Cavin, L. - Johnson Pokorná, Martina - Doležálková, Marie - Flajšhans, M. - Normandeau, E. - Ráb, Petr - Meyer, A. - Bernatchez, L.
    Genome Compositional Organization in Gars Shows More Similarities to Mammals than to Other Ray-Finned Fish.
    Journal of Experimental Zoology Part B: Molecular and Developmental Evolution Additional Title Information. Roč. 328, č. 7 (2017), s. 607-619. ISSN 1552-5007. E-ISSN 1552-5015
    Grant CEP: GA ČR(CZ) GPP506/11/P596; GA ČR GA14-02940S
    Institucionální podpora: RVO:67985904
    Klíčová slova: biased gene conversion * cold-blooded vertebrates * density gradient centrifugation
    Obor OECD: Biology (theoretical, mathematical, thermal, cryobiology, biological rhythm), Evolutionary biology
    Impakt faktor: 2.432, rok: 2017

    Genomic GC content can vary locally, and GC-rich regions are usually associated with increased DNA thermostability in thermophilic prokaryotes and warm-blooded eukaryotes. Among vertebrates, fish and amphibians appeared to possess a distinctly less heterogeneous AT/GC organization in their genomes, whereas cytogenetically detectable GC heterogeneity has so far only been documented in mammals and birds. The subject of our study is the gar, an ancient living fossil of a basal ray-finned fish lineage, known from the Cretaceous period. We carried out cytogenomic analysis in two gar genera (Atractosteus and Lepisosteus) uncovering a GC chromosomal pattern uncharacteristic for fish. Bioinformatic analysis of the spotted gar (Lepisosteus oculatus) confirmed a GC compartmentalization on GC profiles of linkage groups. This indicates a rather mammalian mode of compositional organization on gar chromosomes. Gars are thus the only analyzed extant ray-finned fishes with a GC compartmentalized genome. Since gars are cold-blooded anamniotes, our results contradict the generally accepted hypothesis that the phylogenomic onset of GC compartmentalization occurred near the origin of amniotes. Ecophysiological findings of other authors indicate a metabolic similarity of gars with mammals. We hypothesize that gars might have undergone convergent evolution with the tetrapod lineages leading to mammals on both metabolic and genomic levels. Their metabolic adaptations might have left footprints in their compositional genome evolution, as proposed by the metabolic rate hypothesis. The genome organization described here in gars sheds new light on the compositional genome evolution in vertebrates generally and contributes to better understanding of the complexities of the mechanisms involved in this process.
    Trvalý link: http://hdl.handle.net/11104/0277257

     
     
Počet záznamů: 1  

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