Počet záznamů: 1  

Ability of polymer-bound P-glycoprotein inhibitor ritonavir to overcome multidrug resistance in various resistant neuroblastoma cell lines

  1. 1.
    0481614 - ÚMCH 2018 RIV US eng J - Článek v odborném periodiku
    Koziolová, Eva - Chytil, Petr - Etrych, Tomáš - Janoušková, Olga
    Ability of polymer-bound P-glycoprotein inhibitor ritonavir to overcome multidrug resistance in various resistant neuroblastoma cell lines.
    Anti-cancer Drugs. Roč. 28, č. 10 (2017), s. 1126-1130. ISSN 0959-4973. E-ISSN 1473-5741
    Grant CEP: GA MŠMT(CZ) LO1507
    Institucionální podpora: RVO:61389013
    Klíčová slova: drug-delivery polymers * multidrug resistance * N-(2-hydroxypropyl) methacrylamide
    Obor OECD: Polymer science
    Impakt faktor: 1.869, rok: 2017

    Polymer prodrugs can considerably improve the treatment of tumors with multidrug resistance, often caused by overexpression of P-glycoprotein (P-gp). Here, we present the effect of the N-(2-hydroxypropyl) methacrylamide-based polymer conjugate with P-gp inhibitor ritonavir (RIT) on the increase of free doxorubicin (DOX) and polymer-bound DOX cytotoxicity in the human neuroblastoma 4 cell line and its resistant clones to different cytostatics. The increase in cytotoxicity after polymer-RIT conjugate pretreatment was higher for the lines overexpressing P-gp and less pronounced for those with decreased P-gp levels. Moreover, the effect of polymer conjugate containing inhibitor and DOX on the same polymer chain was lower than that of two individual polymer conjugates used sequentially. In conclusion, the polymer-RIT conjugate can significantly increase the cytotoxicity of free DOX and polymer-DOX conjugates in cells with various multidrug resistance origins and can thus be considered a suitable therapeutic enhancer of polymer prodrugs.
    Trvalý link: http://hdl.handle.net/11104/0277429

     
     
Počet záznamů: 1  

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