Počet záznamů: 1  

Brain ageing changes proteoglycan sulfation, rendering perineuronal nets more inhibitory

  1. 1.
    0480564 - ÚEM 2018 RIV US eng J - Článek v odborném periodiku
    Foscarin, S. - Raha-Chowdhury, R. - Fawcett, James - Kwok, Jessica
    Brain ageing changes proteoglycan sulfation, rendering perineuronal nets more inhibitory.
    Aging. Roč. 9, č. 6 (2017), s. 1607-1622. ISSN 1945-4589
    Grant CEP: GA MŠk(CZ) EF15_003/0000419
    Institucionální podpora: RVO:68378041
    Klíčová slova: aging * perineuronal net * plasticity * glycosaminoglycans
    Kód oboru RIV: FH - Neurologie, neurochirurgie, neurovědy
    Obor OECD: Neurosciences (including psychophysiology
    Impakt faktor: 5.179, rok: 2017

    Chondroitin sulfate (CS) proteoglycans in perineuronal nets (PNNs) from the central nervous system (CNS) are involved in the control of plasticity and memory. Removing PNNs reactivates plasticity and restores memory in models of Alzheimer's disease and ageing. Their actions depend on the glycosaminoglycan (GAG) chains of CS proteoglycans, which are mainly sulfated in the 4 (C4S) or 6 (C6S) positions. While C4S is inhibitory, C6S is more permissive to axon growth, regeneration and plasticity. C6S decreases during critical period closure. We asked whether there is a late change in CS-GAG sulfation associated with memory loss in aged rats. Immunohistochemistry revealed a progressive increase in C4S and decrease in C6S from 3 to 18 months. GAGs extracted from brain PNNs showed a large reduction in C6S at 12 and 18 months, increasing the C4S/C6S ratio. There was no significant change in mRNA levels of the chondroitin sulfotransferases. PNN GAGs were more inhibitory to axon growth than those from the diffuse extracellular matrix. The 18-month PNN GAGs were more inhibitory than 3-month PNN GAGs. We suggest that the change in PNN GAG sulfation in aged brains renders the PNNs more inhibitory, which lead to a decrease in plasticity and adversely affect memory.
    Trvalý link: http://hdl.handle.net/11104/0276763