Počet záznamů: 1  

Transcriptomic signatures shaped by cell proportions shed light on comparative developmental biology

  1. 1. 0479525 - UEM-P 2018 RIV GB eng J - Článek v odborném periodiku
    Pantalacci, S. - Gueguen, L. - Petit, C. - Lambert, A. - Peterková, Renata - Sémon, E.
    Transcriptomic signatures shaped by cell proportions shed light on comparative developmental biology.
    Genome Biology. Roč. 18, feb (2017), s. 29 ISSN 1474-760X
    Grant CEP: GA ČR(CZ) GB14-37368G
    Institucionální podpora: RVO:68378041
    Klíčová slova: comparative transcriptomics * developmental biology * transcriptomic signature
    Kód oboru RIV: EA - Morfologické obory a cytologie
    Obor OECD: Developmental biology
    Impakt faktor: 13.214, rok: 2017

    Little is known about the kinds of expression differences that shape the patterns during development. Using mouse model of odontogenesis, the transcriptomes were compared and correlated with the development of two morphologically distinct serial organs: the upper and lower first molars that exhibit specific tooth morphology and cusp pattern. 1) The, lower/upper molar differences were maintained throughout morphogenesis and stem from differences in the relative abundance of mesenchyme and from constant differences in gene expression within tissues. 2) There were clear time-shift differences in the transcriptomes of the two molars related to cusp tissue abundance. 3) The transcriptomes corresponded to exaggerated morphogenetic processes in the upper molar involving fewer mitotic cells but more migrating cells.
    CONCLUSIONS: Gene expression in a complex tissue reflects not only transcriptional regulation but also abundance of different cell types.

    Trvalý link: http://hdl.handle.net/11104/0275739