Počet záznamů: 1  

Lambda phage genetic switch as a system with critical behaviour

  1. 1.
    0479051 - MBU-M 2018 RIV GB eng J - Článek v odborném periodiku
    Vohradský, Jiří
    Lambda phage genetic switch as a system with critical behaviour.
    Journal of Theoretical Biology. Roč. 431, OCT 27 2017 (2017), s. 32-38. ISSN 0022-5193
    Grant CEP: GA MŠk(CZ) LM2015055
    Institucionální podpora: RVO:61388971
    Klíčová slova: Critical behaviour * Phage lambda * Genetic networks
    Kód oboru RIV: EE - Mikrobiologie, virologie
    Obor OECD: Microbiology
    Impakt faktor: 1.833, rok: 2017

    Critical behaviour pervades scientific disciplines as diverse as geology, economy or sociology. The critical behaviour of cell control systems is an open issue whose role has not yet been fully explored. The control of the expression of lambda phage DNA in the host cell can be classified as a system with critical behaviour. Lambda phage is a virus that infects Escherichia coli. Its core genes maintain one of two states, lysogeny or lysis. Current knowledge of the lambda phage genetic network allows to build a computational model of transcriptional control of the genes involved in the lytic-lysogenic switch and to simulate the temporal changes of their expression. Here, we focused on the computational simulation of these gene expressions to demonstrate critical behaviour of the system.
    Trvalý link: http://hdl.handle.net/11104/0275250