0477601 - BÚ 2018 RIV US eng J - Článek v odborném periodiku
Salmina, K. - Huna, A. - Inashkina, I. - Belyayev, Alexander - Krigerts, J. - Paštová, Ladislava - Vazquez-Martin, A. - Erenpreisa, J.
Nucleolar aggresomes mediate release of pericentric heterochromatin and nuclear destruction of genotoxically treated cancer cells.
Nucleus. Roč. 8, č. 2 (2017), s. 205-221. ISSN 1949-1034. E-ISSN 1949-1042
Institucionální podpora: RVO:67985939
Klíčová slova: aggresome * ALU retrotransposition * autophagy
Obor OECD: Cell biology
Impakt faktor: 2.210, rok: 2017

As an origin of heterochromatin fragmentation, the unscheduled DNA synthesis and circular DNAs were found in the perinucleolar heterochromatin shell, along with activation and retrotransposition of ALU elements, colocalised with 45S rDNA in NoAs. The data indicate coordination of the basic nucleolar function with autophagy regulation in maintenance of the integrity of the nucleolus associated domains secured by inactivity of retrotransposons.
Trvalý link: http://hdl.handle.net/11104/0277194