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Transcriptomic response of Arabidopsis thaliana (L.) Heynh. roots to ibuprofen

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    0476651 - ÚEB 2018 RIV US eng J - Článek v odborném periodiku
    Landa, Přemysl - Přerostová, Sylva - Langhansová, Lenka - Maršík, Petr - Vaněk, Tomáš
    Transcriptomic response of Arabidopsis thaliana (L.) Heynh. roots to ibuprofen.
    International Journal of Phytoremediation. Roč. 19, č. 8 (2017), s. 695-700. ISSN 1522-6514. E-ISSN 1549-7879
    Grant CEP: GA ČR(CZ) GA14-22593S
    Institucionální podpora: RVO:61389030
    Klíčová slova: detoxification * gene expression * metabolism of xenobiotics * microarrays * phytoremediation
    Obor OECD: Plant sciences, botany
    Impakt faktor: 1.886, rok: 2017

    Surface waters in urban areas are contaminated by ibuprofen (IBP), a popular and extensively used anti-inflammatory drug. In this study, we investigated the transcriptomic response in Arabidopsis thaliana (L.) Heynh. roots with the aim of revealing genes that are potentially involved in IBP detoxification and elucidating the effect of IBP on plants. IBP upregulated 63 and downregulated 38 transcripts (p-value < 0.1, fold change ≥2) after 2-day exposure to a 5-µM (1.03 mg/L) concentration of IBP under hydroponic conditions. Although the IBP concentration used in the experiment was highly relative to the concentrations found in rivers and wastewater, the number of genes with transcriptional changes was relatively low. The upregulation of cytochrome P450s, glutathione S-transferases, and UDP-glycosyltransferases indicates the occurrence of IBP oxidation in the first phase, followed by conjugation with glutathione and sugar in the second detoxification phase. ABC transporters could be involved in the transport of IBP and its metabolites. The identification of genes potentially involved in IBP detoxification could be useful in an IBP phytoremediation approach.
    Trvalý link: http://hdl.handle.net/11104/0273115

     
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