Počet záznamů: 1  

Plasma Phospholipid Fatty Acid Profile is Altered in Both Septic and Non-Septic Critically Ill: A Correlation with Inflammatory Markers and Albumin

  1. 1. 0474690 - FGU-C 2018 RIV US eng J - Článek v odborném periodiku
    Novák, F. - Borovská, J. - Vecka, M. - Rychlíková, J. - Vávrová, L. - Petrásková, H. - Žák, A. - Nováková, Olga
    Plasma Phospholipid Fatty Acid Profile is Altered in Both Septic and Non-Septic Critically Ill: A Correlation with Inflammatory Markers and Albumin.
    Lipids. Roč. 52, č. 3 (2017), s. 245-254. ISSN 0024-4201
    Institucionální podpora: RVO:67985823
    Klíčová slova: sepsis * inflammation * oxidative stress * plasma lipids * fatty acid profile * PUFA * lipoproteins
    Kód oboru RIV: FB - Endokrinologie, diabetologie, metabolizmus, výživa
    Obor OECD: Critical care medicine and Emergency medicine
    Impakt faktor: 1.936, rok: 2017

    This study analyzes fatty acid (FA) composition in plasma lipids and erythrocyte phospholipids while comparing septic and non-septic critically ill patients. The aim was to describe impacts of infection and the inflammatory process. Patients with severe sepsis (SP, n = 13), age-, sex- and APACHE II score-matched non-septic critically ill with systemic inflammatory response syndrome (NSP, n = 13), and age-/sex-matched healthy controls (HC, n = 13) were included in a prospective case-control study during the first 24 h after admission to the intensive care unit. In both SP and NSP, lower n-6 polyunsaturated FA (PUFA) accompanied by higher proportions of monounsaturated FA (MUFA) in plasma phospholipids (PPL) was observed relative to HC. MUFA proportion was negatively correlated with n-6 PUFA, high density lipoprotein cholesterol (HDL-C), and albumin. MUFA was positively correlated with C-reactive protein (CRP), procalcitonin (PCT), interleukins (IL-6, IL-10), oxidized low density lipoproteins (ox-LDL), and conjugated dienes (CD). In both SP and NSP, inflammatory and lipid peroxidation markers were significantly higher-CRP (p < 0.001, p = 0.08), IL-6, IL-10, TNF-alpha (p < 0.01, p = 0.06), ox-LDL, and CD while total cholesterol, HDL-C, LDL-C albumin, and 20:4n-6/22:6n-3 and n-6/n-3 ratios were lower compared to HC. In conclusion, the changes in plasma lipid FA profile relate to the intensity of inflammatory and peroxidative response regardless of insult etiology. The lower MUFA and higher n-6 PUFA proportions in PPL were inversely correlated with cholesterol and albumin levels.
    Trvalý link: http://hdl.handle.net/11104/0271688