Počet záznamů: 1  

Increased Binding of Calcium Ions at Positively Curved Phospholipid Membranes

  1. 1. 0474257 - UOCHB-X 2018 RIV US eng J - Článek v odborném periodiku
    Magarkar, Aniket - Jurkiewicz, Piotr - Allolio, Christoph - Hof, Martin - Jungwirth, Pavel
    Increased Binding of Calcium Ions at Positively Curved Phospholipid Membranes.
    Journal of Physical Chemistry Letters. Roč. 8, č. 2 (2017), s. 518-523 ISSN 1948-7185
    Grant CEP: GA ČR(CZ) GA16-01074S; GA ČR(CZ) GAP207/12/0919
    Grant ostatní:AV ČR(CZ) AP1102
    Program:Akademická prémie - Praemium Academiae
    Institucionální podpora: RVO:61388963 ; RVO:61388955
    Klíčová slova: molecular dynamics * fluorescence spectroscopy * calcium * phospholipids
    Kód oboru RIV: CF - Fyzikální chemie a teoretická chemie; CF - Fyzikální chemie a teoretická chemie (UFCH-W)
    Obor OECD: Physical chemistry; Physical chemistry (UFCH-W)
    Impakt faktor: 8.709, rok: 2017

    Calcium ion is the ubiquitous messenger in cells and plays a key role in neuronal signaling and fusion of synaptic vesicles. These vesicles are typically similar to 20-50 nm in diameter, and thus their interaction with calcium ions cannot be modeled faithfully with a conventional flat membrane bilayer setup. Within our newly developed molecular dynamics simulations setup, we characterize here interactions of the calcium ion with curved membrane interfaces with atomistic detail. The present molecular dynamics simulations together with time-dependent fluorescence shift experiments suggest that the mode and strength of interaction of calcium ion with a phospholipid bilayer depends on its curvature. Potential of mean force calculations demonstrate that the binding of calcium ion to the positively curved side of the bilayer is significantly stronger compared with that to a flat membrane.
    Trvalý link: http://hdl.handle.net/11104/0271384