Lipopeptides as therapeutics: applications and in vivo quantitative analysis

0474026 - FGÚ 2018 RIV GB eng J - Článek v odborném periodiku
Zemenová, J. - Sýkora, D. - Maletínská, L. - Kuneš, Jaroslav
Lipopeptides as therapeutics: applications and in vivo quantitative analysis.
Bioanalysis. Roč. 9, č. 2 (2017), s. 215-230. ISSN 1757-6180. E-ISSN 1757-6199
Grant CEP: GA ČR(CZ) GA15-08679S
Institucionální podpora: RVO:67985823
Klíčová slova: immunomethods * LC-MS * lipopeptides
Obor OECD: Endocrinology and metabolism (including diabetes, hormones)
Impakt faktor: 2.478, rok: 2017

A number of novel lipopeptides have been studied for their possible therapeutic potential. These studies should be supported by the appropriate analytical tools not only for novel potential drugs but also for their metabolites, precursors and side products. Lipopeptides have specific physicochemical properties that make them successful in medical applications. However, there are some difficulties with their qualitative and quantitative analyses in biological samples. Therefore, reliable, sensitive and robust analytical methods are in high demand. The main interest of our review is to describe a selection of specific and important properties of lipopeptides, and the analytical methods currently utilized for their characterization and determination in biological samples. A comparison of the pros and cons of immunomethods versus LC–MS methods is discussed in detail.
Trvalý link: http://hdl.handle.net/11104/0271124