Kinetic, thermodynamic and structural analysis of tamiphosphor binding to neuraminidase of H1N1 (2009) pandemic influenza

0473216 - ÚMG 2017 RIV FR eng J - Článek v odborném periodiku
Albinana, C. B. - Machara, A. - Řezáčová, Pavlína - Pachl, P. - Konvalinka, J. - Kožíšek, M.
Kinetic, thermodynamic and structural analysis of tamiphosphor binding to neuraminidase of H1N1 (2009) pandemic influenza.
European Journal of Medicinal Chemistry. Roč. 121, OCT 4 (2016), s. 100-109. ISSN 0223-5234. E-ISSN 1768-3254
Institucionální podpora: RVO:68378050
Klíčová slova: Influenza neuraminidase * Oseltamivir * Tamiphosphor * Isothermal titration calorimetry * Crystal structure * Lattice-translocation defect
Kód oboru RIV: EB - Genetika a molekulární biologie
Impakt faktor: 4.519, rok: 2016

Influenza virus causes severe respiratory infections that are responsible for up to half a million deaths worldwide each year. Two inhibitors targeting viral neuraminidase have been approved to date (oseltamivir, zanamivir). However, the rapid development of antiviral drug resistance and the efficient transmission of resistant viruses among humans represent serious threats to public health.
Trvalý link: http://hdl.handle.net/11104/0270375