Počet záznamů: 1  

When viruses don’t go viral: the importance of host phylogeographic structure in the spatial spread of arenaviruses

  1. 1.
    0472353 - ÚBO 2017 RIV US eng J - Článek v odborném periodiku
    Gryseels, S. - Baird, Stuart J. E. - Borremans, B. - Makundi, R. - Leirs, H. - Goüy de Bellocq, Joëlle
    When viruses don’t go viral: the importance of host phylogeographic structure in the spatial spread of arenaviruses.
    PLoS Pathogens. Roč. 13, č. 1 (2017), č. článku e1006073. ISSN 1553-7366. E-ISSN 1553-7374
    Grant CEP: GA ČR(CZ) GA14-35009S; GA ČR GA15-13265S; GA ČR GA15-20229S; GA ČR GCP502/11/J070
    Institucionální podpora: RVO:68081766
    Klíčová slova: habitat * human * Lassa virus * Mastomys natalensis * nonhuman * Tanzania
    Obor OECD: Virology
    Impakt faktor: 6.158, rok: 2017

    Many emerging infections are RNA virus spillovers from animal reservoirs. Reservoir identification is necessary for predicting the geographic extent of infection risk, but rarely are taxonomic levels below the animal species considered as reservoir, and only key circumstances in nature and methodology allow intrinsic virus-host associations to be distinguished from simple geographic (co-)isolation. We sampled and genetically characterized in detail a contact zone of two subtaxa of the rodent Mastomys natalensis in Tanzania. We find two distinct arenaviruses, Gairo and Morogoro virus, each spatially confined to a single M. natalensis subtaxon, only co-occurring at the contact zone’s centre. Inter-subtaxon hybridization at this centre and a continuum of quality habitat for M. natalensis show that both viruses have the ecological opportunity to spread into the other substaxon’s range, but do not, strongly suggesting host-intrinsic barriers. Such barriers could explain why human cases of another M. natalensis-borne arenavirus, Lassa virus, are limited to West Africa.
    Trvalý link: http://hdl.handle.net/11104/0269677

     
     
Počet záznamů: 1  

  Tyto stránky využívají soubory cookies, které usnadňují jejich prohlížení. Další informace o tom jak používáme cookies.