Počet záznamů: 1  

Methoxychlor and vinclozolin induce rapid changes in intercellular and intracellular signaling in liver progenitor cells

  1. 1.
    0471908 - BÚ 2017 RIV US eng J - Článek v odborném periodiku
    Babica, Pavel - Zurabian, R. - Kumar, E. R. - Chopra, R. - Mianecki, M. J. - Park, J.-S. - Jaša, Libor - Trosko, J. E. - Upham, B. L.
    Methoxychlor and vinclozolin induce rapid changes in intercellular and intracellular signaling in liver progenitor cells.
    Toxicological Sciences. Roč. 153, č. 1 (2016), s. 174-185. ISSN 1096-6080. E-ISSN 1096-0929
    Grant CEP: GA MŠMT LH12034
    Institucionální podpora: RVO:67985939
    Klíčová slova: endocrine disrupters * gap junctional intercellular communication * resveratrol
    Kód oboru RIV: EB - Genetika a molekulární biologie
    Impakt faktor: 4.081, rok: 2016

    Endocrine disruptors interfere with physiological hormonal regulations. We showed using mammalian cell cultures that endocrine disruptors methoxychlor and vinclozolin can elicit effects also independently of estrogen- or androgen-receptor. In this way, they can disrupt gap junctional intercellular communication or activity of signal transduction enzymes. These findings improve our understanding about mode of action of these important environmental contaminants and their human health impacts.
    Trvalý link: http://hdl.handle.net/11104/0269541

     
     
Počet záznamů: 1  

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