Počet záznamů: 1  

Parasite Cathepsin D-Like Peptidases and Their Relevance as Therapeutic Targets

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    0471803 - ÚOCHB 2017 RIV GB eng J - Článek v odborném periodiku
    Sojka, D. - Hartmann, D. - Bartošová-Sojková, P. - Dvořák, Jan
    Parasite Cathepsin D-Like Peptidases and Their Relevance as Therapeutic Targets.
    Trends in Parasitology. Roč. 32, č. 9 (2016), s. 708-723. ISSN 1471-4922. E-ISSN 1471-5007
    Grant CEP: GA ČR GA13-11043S; GA ČR(CZ) GAP302/11/1481
    Institucionální podpora: RVO:61388963
    Klíčová slova: aspartic peptidases * cathepsin D * hemoglobinolysis * parasites * vectors
    Kód oboru RIV: CE - Biochemie
    Impakt faktor: 6.333, rok: 2016

    Inhibition of aspartic cathepsin D-like peptidases (APDs) has been often discussed as an antiparasite intervention strategy. APDs have been considered as virulence factors of Ttypanosoma cruzi and Leishmania spp., and have been demonstrated to have important roles in protein trafficking mechanisms of apicomplexan parasites. APDs also initiate blood digestion as components of multienzyme proteolytic complexes in malaria, platyhelminths, nematodes, and ticks. Increasing DNA and RNA sequencing data indicate that parasites express multiple APD isoenzymes of various functions that can now be specifically evaluated using new functional-genomic and biochemical tools, from which we can further assess the potential of APDs as targets for novel effective intervention strategies against parasitic diseases that still pose an alarming threat to mankind.
    Trvalý link: http://hdl.handle.net/11104/0269132

     
     
Počet záznamů: 1  

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