Počet záznamů: 1  

Drosophila imaginal disc growth factor 2 is a trophic factor involved in energy balance, detoxification, and innate immunity

  1. 1. 0471527 - BC-A 2018 RIV GB eng J - Článek v odborném periodiku
    Brož, Václav - Kučerová, Lucie - Rouhová, L. - Fleischmannová, Jana - Strnad, Hynek - Bryant, P. J. - Žurovec, Michal
    Drosophila imaginal disc growth factor 2 is a trophic factor involved in energy balance, detoxification, and innate immunity.
    Scientific Reports. Roč. 7, FEB 23 (2017), č. článku 43273. ISSN 2045-2322
    Grant CEP: GA ČR GA14-27816S; GA ČR GA14-07172S
    Institucionální podpora: RVO:60077344 ; RVO:68378050
    Klíčová slova: Drosophila * innate immunity * IDGF2
    Kód oboru RIV: CE - Biochemie; CE - Biochemie (UMG-J)
    Obor OECD: Biochemistry and molecular biology; Biochemistry and molecular biology (UMG-J)
    Impakt faktor: 4.122, rok: 2017
    http://www.nature.com/articles/srep43273

    Drosophila imaginal disc growth factors (IDGFs) are a family of chitinase-like glycoproteins abundantly secreted into the hemolymph by fat body and hemocytes.We show that the prototypical member, IDGF2, is an insulin-independent trophic and protective factor in cultured insect cells as well as in intact /Drosophila/ larvae and adults. It protects cells from death caused by serum deprivation, toxicity of xenobiotics or high concentrations of extracellular adenosine (Ado) and deoxyadenosine (dAdo).Recombinant IDGF2 is able to renew the mitochondrial and cellular energy homeostasis and prevent the dissipation of mitochondrial membrane potential (delta-psi(m) in cultured cells. Transcriptional profiling supported the role of IDGF2 in energy metabolism, detoxification and innate immunity. We also show that IDGF2 is induced by injury in larval stages. The highest IDGF2 accumulation found at garland and pericardial nephrocytes is also consistent with its role in organismal detoxification. Taken together, IDGF2 has similar overall homeostatic and protective effect as mammalian serum and chitinase-like glycoproteins recently associated with pathogenic processes related to inflammation, extracellular tissue remodeling, fibrosis and solid carcinomas.


    Trvalý link: http://hdl.handle.net/11104/0271169