Počet záznamů: 1  

Novel methods of treating ovarian infertility in older and POF women, testicular infertility, and other human functional diseases

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    0470483 - BTÚ 2017 RIV US eng J - Článek v odborném periodiku
    Bukovský, Antonín
    Novel methods of treating ovarian infertility in older and POF women, testicular infertility, and other human functional diseases.
    Reproductive Biology and Endocrinology. Roč. 13, Feb 25 (2015), č. článku 10. E-ISSN 1477-7827
    Institucionální podpora: RVO:86652036
    Klíčová slova: In vitro maturation * in vitro fertilization * ovarian stem cells
    Kód oboru RIV: FB - Endokrinologie, diabetologie, metabolizmus, výživa
    Impakt faktor: 2.147, rok: 2015

    In vitro maturation (IVM) and in vitro fertilization (IVF) technologies are facing with growing demands of older women to conceive. Although ovarian stem cells (OSCs) of older women are capable of producing in vitro fresh oocyte-like cells (OLCs), such cells cannot respond to IVM and IVF due to the lack of granulosa cells required for their maturation. Follicular renewal is also dependent on support of circulating blood mononuclear cells. A pretreatment of OSC culture with mononuclear cells collected from blood of a young healthy fertile woman may cause differentiation of bipotential OSCs into both developing germ and granulosa cells. A small blood volume replacement may enable treatment of ovarian infertility in vivo. The transferred mononuclear cells may temporarily rejuvenate virtually all tissues, including improvement of the function of endocrine tissues. Formation of new follicles and their development may be sufficient for IVM and IVF. The novel proposed in vitro approaches may be used as a second possibility. Infertility of human males affects almost a half of the infertility cases worldwide. Small blood volume replacement from young healthy fertile men may also be easy approach for the improvement of sperm quality in older or other affected men. Here we propose for the first time that blood mononuclear cells are essential for rejuvenation of those tissues, where immune system components participate in an appropriate division and differentiation of tissue stem cells. If needed, small blood volume replacement from distinct young healthy individuals could be utilized in six month intervals for repair of young altered or aged reproductive and other tissue functions. Systemic and local use of honey bee propolis tincture is an alternative option for functional rejuvenation of some tissues.
    Trvalý link: http://hdl.handle.net/11104/0268108

     
     
Počet záznamů: 1  

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