MicroRNA in Metabolic Re-Programming and Their Role in Tumorigenesis

0470415 - BTÚ 2020 RIV CH eng J - Článek v odborném periodiku
Tomasetti, M. - Amati, M. - Santarelli, L. - Neužil, Jiří
MicroRNA in Metabolic Re-Programming and Their Role in Tumorigenesis.
International Journal of Molecular Sciences. Roč. 17, č. 5 (2016), č. článku 754. E-ISSN 1422-0067
Institucionální podpora: RVO:86652036
Klíčová slova: miRNAs * tumorigenesis * miR-126 and cancer-stroma environment * metabolic reprogramming
Obor OECD: Biochemistry and molecular biology
Impakt faktor: 3.226, rok: 2016
Způsob publikování: Open access
https://www.mdpi.com/1422-0067/17/5/754

The process of metabolic re-programing is linked to the activation of oncogenes and/or suppression of tumour suppressor genes, which are regulated by microRNAs (miRNAs). The interplay between oncogenic transformation-driven metabolic re-programming and modulation of aberrant miRNAs further established their critical role in the initiation, promotion and progression of cancer by creating a tumorigenesis-prone microenvironment, thus orchestrating processes of evasion to apoptosis, angiogenesis and invasion/migration, as well metastasis. Given the involvement of miRNAs in tumour development and their global deregulation, they may be perceived as biomarkers in cancer of therapeutic relevance.
Trvalý link: http://hdl.handle.net/11104/0268056