Počet záznamů: 1  

LACE1 interacts with p53 and mediates its mitochondrial translocation and apoptosis

  1. 1.
    0469444 - FGÚ 2017 RIV US eng J - Článek v odborném periodiku
    Česneková, J. - Spáčilová, J. - Hansíková, H. - Houštěk, Josef - Zeman, J. - Stibůrek, L.
    LACE1 interacts with p53 and mediates its mitochondrial translocation and apoptosis.
    OncoTarget. Roč. 7, č. 30 (2016), s. 47687-47698. ISSN 1949-2553
    Grant CEP: GA ČR(CZ) GA13-07223S
    Institucionální podpora: RVO:67985823
    Klíčová slova: p53 * LACE1 * mitochondria * apoptosis * translocation
    Kód oboru RIV: EB - Genetika a molekulární biologie
    Impakt faktor: 5.168, rok: 2016

    p53 is a major cellular tumor suppressor that in addition to its nuclear, transcription-dependent activity is also known to function extranuclearly. Cellular stressors such as reactive oxygen species can promote translocation of p53 into mitochondria where it acts to protect mitochondrial genome or trigger cell death via transcription-independent manner. Here we report that the mammalian homologue of yeast mitochondrial Afg1 ATPase (LACE1) promotes translocation of p53 into mitochondria. We further show that LACE1 exhibits significant pro-apoptotic activity, which is dependent on p53, and that the protein is required for normal mitochondrial respiratory function. LACE1 physically interacts with p53 and is necessary for mitomycin c-induced translocation of p53 into mitochondria. Conversely, increased expression of LACE1 partitions p53 to mitochondria, causes reduction in nuclear p53 content and induces apoptosis. Thus, LACE1 mediates mitochondrial translocation of p53 and its transcription-independent apoptosis.
    Trvalý link: http://hdl.handle.net/11104/0267244

     
     
Počet záznamů: 1  

  Tyto stránky využívají soubory cookies, které usnadňují jejich prohlížení. Další informace o tom jak používáme cookies.