0467503 - ÚFCH JH 2017 RIV US eng J - Článek v odborném periodiku
Zakharov, S. - Pelclová, D. - Diblík, P. - Urban, P. - Kuthan, P. - Nurieva, O. - Kotíková, K. - Navrátil, Tomáš - Komarc, M. - Běláček, J. - Seidl, Z. - Vaněčková, M. - Hubáček, J. A. - Bezdíček, O. - Klempíř, J. - Yurchenko, M. - Růžička, E. - Miovský, M. - Janíková, B. - Hovda, K. E.
Long-term visual damage after acute methanol poisonings: Longitudinal cross-sectional study in 50 patients.
Clinical Toxicology. Roč. 53, č. 9 (2015), s. 884-892. ISSN 1556-3650. E-ISSN 1556-9519
Institucionální podpora: RVO:61388955
Klíčová slova: acute methanol poisoning * hospital treatment * treatment outcome
Kód oboru RIV: CF - Fyzikální chemie a teoretická chemie
Impakt faktor: 2.886, rok: 2015 ; AIS: 0.799, rok: 2015
DOI: https://doi.org/10.3109/15563650.2015.1086488

Context. Visual disturbances due to the toxic effect of formic acid in acute methanol poisonings are generally transient. The subjective symptoms of visual toxicity may resolve within few weeks and fundoscopic signs of acute optic neuropathy subside within 1-2 months; therefore, the prevalence of long-term visual sequelae in the population of survivors of poisonings may be underestimated. Objective. To study the prevalence and character of long-term visual sequelae of acute methanol poisonings based on the data from the Czech mass methanol outbreak in 2012. Patients and methods. A total of 50 patients with confirmed methanol poisoning were included in this longitudinal cross-sectional study, median age: 48 (range, 23-73) years. The following tests were performed: optical coherence tomography or OCT with evaluation of the retinal nerve fibers layer (RNFL), visual evoked potentials (VEP), magnetic resonance imaging (MRI) of brain, complete ocular examination (visual acuity/field, color vision, contrast sensitivity, and fundus), neurological examinations, and biochemical tests. Results. Of 50 patients, 7/50 (14%) were discharged with diagnosed visual sequelae and 6/50 (12%) were discharged with both visual and central nervous system sequelae of poisoning. On the follow-up examination, 20/50 (40%) of the patients had long-term visual sequelae, with 8% of blindness. A total of 38% of the patients had abnormal (28% borderline) findings on RNFL, and 40% had abnormal (18% borderline) VEP. Among the patients discharged without detected visual sequelae, 8/37 (22%) had abnormal RNFL and VEP. Patients with visual sequelae had brain lesions more often (70% vs. 27%, p < 0.01)...
Trvalý link: http://hdl.handle.net/11104/0265594