Počet záznamů: 1  

The functional organization of human epileptic hippocampus

  1. 1.
    0466972 - ÚPT 2017 RIV US eng J - Článek v odborném periodiku
    Klimeš, Petr - Duque, J. J. - Brinkmann, B. - Gompel, J.V. - Stead, M. - St Louis, E. K. - Halámek, Josef - Jurák, Pavel - Worrell, G. A.
    The functional organization of human epileptic hippocampus.
    Journal of Neurophysiology. Roč. 115, č. 6 (2016), s. 3140-3145. ISSN 0022-3077. E-ISSN 1522-1598
    Grant CEP: GA ČR GAP103/11/0933; GA MŠMT ED0017/01/01; GA MŠMT(CZ) LO1212
    Institucionální podpora: RVO:68081731
    Klíčová slova: intracranial EEG * epilepsy * seizure onset zone * behavioral state * connectivity
    Kód oboru RIV: FH - Neurologie, neurochirurgie, neurovědy
    Impakt faktor: 2.396, rok: 2016

    The function and connectivity of human brain is disrupted in epilepsy. We previously reported that the region of epileptic brain generating focal seizures, i.e., the seizure onset zone (SOZ), is functionally isolated from surrounding brain regions in focal neocortical epilepsy. The modulatory effect of behavioral state on the spatial and spectral scales over which the reduced functional connectivity occurs, however, is unclear. Here we use
    simultaneous sleep staging from scalp EEG with intracranial EEG recordings from medial temporal lobe to investigate how behavioral state modulates the spatial and spectral scales of local field potential synchrony
    in focal epileptic hippocampus. The local field spectral power and linear correlation between adjacent electrodes provide measures of neuronal population synchrony at different spatial scales, respectively. Our results show increased connectivity inside the SOZ and low
    connectivity between electrodes in SOZ and outside the SOZ. During slow-wave sleep, we observed decreased connectivity for ripple and fast ripple frequency bands within the SOZ at the 10 mm spatial scale, while
    the local synchrony remained high at the 1 mm spatial scale. Further study of these phenomena may prove useful for SOZ localization and help understand seizure generation, and the functional deficits seen in epileptic eloquent cortex.
    Trvalý link: http://hdl.handle.net/11104/0265141

     
     
Počet záznamů: 1  

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