Počet záznamů: 1  

Synthesis and Determination of Physicochemical Properties of New 3-(4-Arylpiperazin-1-yl)-2-hydroxypropyl 4-Alkoxyethoxybenzoates

  1. 1.
    0466771 - ÚVGZ 2017 RIV CH eng J - Článek v odborném periodiku
    Marvanová, P. - Padrtová, T. - Odehnalová, K. - Hošík, O. - Oravec, Michal - Mokrý, P.
    Synthesis and Determination of Physicochemical Properties of New 3-(4-Arylpiperazin-1-yl)-2-hydroxypropyl 4-Alkoxyethoxybenzoates.
    Molecules. Roč. 21, č. 12 (2016), č. článku 1682. E-ISSN 1420-3049
    Grant CEP: GA MŠMT(CZ) LM2015061; GA MŠMT(CZ) LO1415
    Výzkumná infrastruktura: CzeCOS II - 90061
    Institucionální podpora: RVO:67179843
    Klíčová slova: arylcarbonyloxyaminopropanols * phenylpiperazines * pKa determination * lipophilicity index * Lipinski rules * blood–brain barrier
    Kód oboru RIV: EH - Ekologie - společenstva
    Impakt faktor: 2.861, rok: 2016

    Nine new dihydrochloride salts of 3-(4-arylpiperazin-1-yl)-2-hydroxypropyl 4-alkoxyethoxybenzoates were designed and synthesized. The physicochemical properties such as lipophilicity index (log kw) and dissociation constant (pKa) were experimentally determined and compared to the software calculated data. The lipophilicity index was determined by means of reversed-phase high performance liquid chromatography (RP-HPLC). The pKa values were determined by means of capillary zone electrophoresis. The “drug-likeness” properties according to the Lipinski Rule of Five and prediction of possible blood–brain barrier penetration were computed and discussed.
    Trvalý link: http://hdl.handle.net/11104/0265009

     
     
Počet záznamů: 1  

  Tyto stránky využívají soubory cookies, které usnadňují jejich prohlížení. Další informace o tom jak používáme cookies.