Počet záznamů: 1  

Modulation of collective cell behaviour by geometrical constraints

  1. 1.
    0466268 - FZÚ 2017 RIV GB eng J - Článek v odborném periodiku
    Lunova, M. - Zablotskyy, Vitaliy A. - Dempsey, N.M. - Devillers, T. - Jirsa, M. - Syková, E. - Kubinová, Šárka - Lunov, Oleg - Dejneka, Alexandr
    Modulation of collective cell behaviour by geometrical constraints.
    Integrative Biology. Roč. 8, č. 11 (2016), s. 1099-1110. ISSN 1757-9694. E-ISSN 1757-9708
    Grant CEP: GA AV ČR(CZ) Fellowship J. E. Purkyně
    Grant ostatní: AV ČR(CZ) Fellowship J. E. Purkyně
    Program: Fellowship J. E. Purkyně
    Institucionální podpora: RVO:68378271
    Klíčová slova: modulation * collective cell * geometrical constraints
    Kód oboru RIV: BO - Biofyzika
    Impakt faktor: 3.252, rok: 2016

    Intracellular and extracellular mechanical forces play a crucial role during tissue growth, modulating nuclear
    shape and function and resulting in complex collective cell behaviour. However, the mechanistic understanding
    of how the orientation, shape, symmetry and homogeneity of cells are affected by environmental geometry is
    still lacking. Here we investigate cooperative cell behaviour and patterns under geometric constraints created by
    topographically patterned substrates. We show how cells cooperatively adopt their geometry, shape, positioning
    of the nucleus and subsequent proliferation activity. Our findings indicate that geometric constraints induce
    significant squeezing of cells and nuclei, cytoskeleton reorganization, drastic condensation of chromatin
    resulting in a change in the cell proliferation rate and the anisotropic growth of cultures.
    Trvalý link: http://hdl.handle.net/11104/0264612

     
     
Počet záznamů: 1  

  Tyto stránky využívají soubory cookies, které usnadňují jejich prohlížení. Další informace o tom jak používáme cookies.