Počet záznamů: 1  

Comparative study on toxicity of extracellularly biosynthesized and laboratory synthesized CdTe quantum dots

  1. 1. 0465910 - UEK-B 2018 RIV NL eng J - Článek v odborném periodiku
    Komínková, M. - Milosavljevic, V. - Vítek, Petr - Polanská, H. - Číhalová, K. - Dostálová, S. - Hynstová, V. - Guran, R. - Kopel, P. - Richtera, L. - Masarik, M. - Brtnický, M. - Kynický, J. - Zítka, O. - Adam, V.
    Comparative study on toxicity of extracellularly biosynthesized and laboratory synthesized CdTe quantum dots.
    Journal of Biotechnology. Roč. 241, JAN (2017), s. 193-200. ISSN 0168-1656
    Grant CEP: GA MŠk(CZ) LO1415
    Institucionální podpora: RVO:67179843
    Klíčová slova: Quantum dots * Biosynthesis * Escherichia coli (E. coli) * CdTe * Toxicity
    Kód oboru RIV: EI - Biotechnologie a bionika
    Obor OECD: Environmental biotechnology
    Impakt faktor: 2.533, rok: 2017

    Nanobiosynthesis belongs to the most recent methods for synthesis of nanoparticles. This type of synthesis
    provides many advantages including the uniformity in particle shape and size. The biosynthesis
    has also a significant advantage regarding chemical properties of the obtained particles. In this study, we
    characterized the basic properties and composition of quantum dots (QDs), obtained by the extracellular
    biosynthesis by Escherichia coli. Furthermore, the toxicity of the biosynthesized QDs was compared to
    QDs prepared by microwave synthesis. The obtained results revealed the presence of cyan CdTe QDs after
    removal of substantial amounts of organic compounds, which stabilized the nanoparticle surface. QDs
    toxicity was evaluated using three cell lines Human Foreskin Fibroblast (HFF), Human Prostate Cancer
    cells (PC-3) and Breast Cancer cells (MCF-7) and the MTT assay. The test revealed differences in the toxicity
    between variants of QDs, varying about 10% in the HFF and 30% in the MCF-7 cell lines. The toxicity of
    the biosynthesized QDs to the PC-3 cell lines was about 35% lower in comparison with the QDs prepared
    by microwave synthesis.
    Trvalý link: http://hdl.handle.net/11104/0265967