Fibrin nanostructures for biomedical applications

0463577 - ÚMCH 2017 RIV CZ eng J - Článek v odborném periodiku
Riedelová-Reicheltová, Zuzana - Brynda, Eduard - Riedel, Tomáš
Fibrin nanostructures for biomedical applications.
Physiological Research. Roč. 65, Suppl. 2 (2016), S263-S272. ISSN 0862-8408. E-ISSN 1802-9973
Grant CEP: GA MŠk(CZ) LQ1604
Institucionální podpora: RVO:61389013
Klíčová slova: fibrinogen * fibrin-bound thrombin * nanostructures
Kód oboru RIV: EB - Genetika a molekulární biologie
Impakt faktor: 1.461, rok: 2016
http://www.biomed.cas.cz/physiolres/pdf/65%20Suppl%202/65_S263.pdf

Fibrin is a versatile biopolymer that has been extensively used in tissue engineering. In this paper fibrin nanostructures prepared using a technique based on the catalytic effect of fibrin-bound thrombin are presented. This technique enables surface-attached thin fibrin networks to form with precisely regulated morphology without the development of fibrin gel in bulk solution. Moreover, the influence of changing the polymerization time, along with the antithrombin III and heparin concentrations on the morphology of fibrin nanostructures was explored. The binding of bioactive molecules (fibronectin, laminin, collagen, VEGF, bFGF, and heparin) to fibrin nanostructures was confirmed. These nanostructures can be used for the surface modification of artificial biomaterials designed for different biomedical applications (e.g. artificial vessels, stents, heart valves, bone and cartilage constructs, skin grafts, etc.) in order to promote the therapeutic outcome.
Trvalý link: http://hdl.handle.net/11104/0264454