Počet záznamů: 1
Isolation of live Borrelia burgdorferi sensu lato spirochaetes from patients with undefined disorders and symptoms not typical for Lyme borreliosis
- 1.0463390 - BC 2017 RIV CA eng J - Článek v odborném periodiku
Rudenko, Natalia - Golovchenko, Maryna - Vancová, Marie - Clark, K. - Grubhoffer, Libor - Oliver, J. H., Jr.
Isolation of live Borrelia burgdorferi sensu lato spirochaetes from patients with undefined disorders and symptoms not typical for Lyme borreliosis.
Clinical Microbiology and Infection. Roč. 22, č. 3 (2016), 267.e9-267.e15. ISSN 1198-743X
GRANT EU: European Commission(XE) 278976 - ANTIGONE
Institucionální podpora: RVO:60077344
Klíčová slova: antibiotic treatment * live Borrelia burgdorferi * live Borrelia bissettii * Lyme borreliosis * recovery of live spirochaetes
Kód oboru RIV: FN - Epidemiologie, infek. nemoci a klin. imunologie
Impakt faktor: 5.292, rok: 2016
Lyme borreliosis is a multisystem disorder with a diverse spectrum of clinical manifestations, caused by spirochaetes of the Borrelia burgdorferi sensu lato complex. It is an infectious disease that can be successfully cured by antibiotic therapy in the early stages; however, the possibility of the appearance of persistent signs and symptoms of disease following antibiotic treatment is recognized. It is known that Lyme borreliosis mimics multiple diseases that were never proven to have a spirochaete aetiology. Using complete modified Kelly- Pettenkofer medium we succeeded in cultivating live B. burgdorferi sensu lato spirochaetes from samples taken from people who suffered from undefined disorders, had symptoms not typical for Lyme borreliosis, but who had undergone antibiotic treatment due to a suspicion of having Lyme disease even though they were seronegative. We report the first recovery of live B. burgdorferi sensu stricto from residents of southeastern USA and the first successful cultivation of live Borrelia bissettii- like strain from residents of North America. Our results support the fact that B. bissettii is responsible for human Lyme borreliosis worldwide along with B. burgdorferi s. s. The involvement of new spirochaete species in Lyme borreliosis changes the understanding and recognition of clinical manifestations of this disease. Clinical Microbiology and Infection (C) 2016 European Society of Clinical Microbiology and Infectious Diseases.
Trvalý link: http://hdl.handle.net/11104/0262603