Lactobacillus plantarum strain maintains growth of infant mice during chronic undernutrition

0463320 - MBÚ 2017 RIV US eng J - Článek v odborném periodiku
Schwarzer, Martin - Makki, K. - Storelli, G. - Machuca-Gayet, I. - Šrůtková, Dagmar - Hermanová, Petra - Martino, M.E. - Balmand, S. - Hudcovic, Tomáš - Heddi, A. - Rieusset, J. - Kozáková, Hana - Vidal, H. - Leulier, F.
Lactobacillus plantarum strain maintains growth of infant mice during chronic undernutrition.
Science. Roč. 351, č. 6275 (2016), s. 854-857. ISSN 0036-8075. E-ISSN 1095-9203
Grant CEP: GA ČR(CZ) GAP303/12/0535
Institucionální podpora: RVO:61388971
Klíčová slova: FACTOR-I * SOMATOTROPIC AXIS * BODY GROWTH
Kód oboru RIV: EC - Imunologie
Impakt faktor: 37.205, rok: 2016

In most animal species, juvenile growth is marked by an exponential gain in body weight and size. Here we show that the microbiota of infant mice sustains both weight gain and longitudinal growth when mice are fed a standard laboratory mouse diet or a nutritionally depleted diet. We found that the intestinal microbiota interacts with the somatotropic hormone axis to drive systemic growth. Using monocolonized mouse models, we showed that selected lactobacilli promoted juvenile growth in a strain-dependent manner that recapitulated the microbiota's effect on growth and the somatotropic axis. These findings show that the host's microbiota supports juvenile growt
Trvalý link: http://hdl.handle.net/11104/0262539