Počet záznamů: 1
Sugared biomaterial binding lectins: achievements and perspectives
- 1. 0462996 - MBU-M 2017 RIV GB eng J - Článek v odborném periodiku
Bojarová, Pavla - Křen, Vladimír
Sugared biomaterial binding lectins: achievements and perspectives.
Biomaterials Science. Roč. 4, č. 8 (2016), s. 1142-1160. ISSN 2047-4830
Grant CEP: GA ČR GC15-02578J
Institucionální podpora: RVO:61388971
Klíčová slova: C-TYPE LECTINS * AMPHIPHILIC JANUS GLYCODENDRIMERS * BIOMEDICALLY RELEVANT LECTINS
Kód oboru RIV: CE - Biochemie
Impakt faktor: 4.210, rok: 2016
Lectins, a distinct group of glycan-binding proteins, play a prominent role in the immune system ranging from pathogen recognition and tuning of inflammation to cell adhesion or cellular signalling. The possibilities of their detailed study expanded along with the rapid development of biomaterials in the last decade. The immense knowledge of all aspects of glycan-lectin interactions both in vitro and in vivo may be efficiently used in bioimaging, targeted drug delivery, diagnostic and analytic biological methods. Practically applicable examples comprise photoluminescence and optical biosensors, ingenious three-dimensional carbohydrate microarrays for high-throughput screening, matrices for magnetic resonance imaging, targeted hyperthermal treatment of cancer tissues, selective inhibitors of bacterial toxins and pathogen-recognising lectin receptors, and many others.
Trvalý link: http://hdl.handle.net/11104/0263320