Počet záznamů: 1

The Regulatory Role of Nuclear Factor Kappa B in the Heart of Hereditary Hypertriglyceridemic Rat

  1. 1.
    0459551 - FGU-C 2017 RIV US eng J - Článek v odborném periodiku
    Vranková, S. - Barta, A. - Klimentová, J. - Dovinová, I. - Líšková, Silvia - Dobešová, Zdenka - Pecháňová, O. - Kuneš, Jaroslav - Zicha, Josef
    The Regulatory Role of Nuclear Factor Kappa B in the Heart of Hereditary Hypertriglyceridemic Rat.
    Oxidative Medicine and Cellular Longevity. Roč. 2016, č. 2016 (2016), s. 9814038 ISSN 1942-0900
    Grant CEP: GA MZd(CZ) NV15-25396A
    Institucionální podpora: RVO:67985823
    Klíčová slova: nuclear factor-kB * nitric oxide * reactive oxygen species * heart * hereditary hypertriglyceridemic rats
    Kód oboru RIV: FA - Kardiovaskulární nemoci vč. kardiochirurgie
    Impakt faktor: 4.593, rok: 2016

    Activation of nuclear factor-kB by increased production of reactive oxygen species (ROS) might induce expression of different antioxidant enzymes and nitric oxide synthase (NOS) isoforms. NF-kB inhibition in hereditary hypertriglyceridemic rats led to decreased ROS degradation by superoxide dismutase and to increased cardiac oxidative damage and elevated blood pressure. Under these conditions increased NO generation may represent a counterregulatory mechanism activate by ROS.
    Trvalý link: http://hdl.handle.net/11104/0259737