Synthesis and Comparative Study of Ammonium and Phosphonium Terminated Carbosilane Dendrimers.

0457374 - ÚCHP 2016 IL eng C - Konferenční příspěvek (zahraniční konf.)
Strašák, Tomáš - Müllerová, Monika - Čermák, Jan - Malý, J. - Malý, M. - Wróbel, D.
Synthesis and Comparative Study of Ammonium and Phosphonium Terminated Carbosilane Dendrimers.
Poster Communications Abstracts. -: -, 2015, s. 206. ISBN N.
[EFMC International Symposium on Advances in Synthetic and Medicinal Chemistry /6./. Rehovot (IL), 15.11.2015-18.11.2015]
Institucionální podpora: RVO:67985858
Klíčová slova: CB-DDM * phosphorium * ammonium
Kód oboru RIV: CC - Organická chemie

Here we report synthesis of new library of CB-DDM with both ammonium and phosphonium groups on the periphery. To evaluate the effect of substitution of substitution of nitrogen atom by phosphorus we prepared two series of identical CS_DDM in 1st – 3rd generations which differs only in onium groups (N or P). Comparative study of their cytotoxicity, the ability to form dendriplexes and their transfections through cell membrane will be presented. The results are supported by computational modeling.

Trvalý link: http://hdl.handle.net/11104/0257766