Prolyl Oligopeptidase from the Blood Fluke Schistosoma mansoni: From Functional Analysis to Anti-schistosomal Inhibitors

0455915 - BC 2016 RIV US eng J - Článek v odborném periodiku
Fajtová, P. - Štefanić, S. - Hradilek, M. - Dvořák, Jan - Vondrášek, J. - Jílková, A. - Ulrychová, L. - McKerrow, J.H. - Caffrey, C.R. - Mareš, M. - Horn, M.
Prolyl Oligopeptidase from the Blood Fluke Schistosoma mansoni: From Functional Analysis to Anti-schistosomal Inhibitors.
PLoS Neglected Tropical Diseases. Roč. 9, č. 6 (2015), e0003827. ISSN 1935-2735. E-ISSN 1935-2735
Institucionální podpora: RVO:60077344
Klíčová slova: Schistosoma mansoni * schistosomiasis * prolyl oligopeptidase * blood fluke
Kód oboru RIV: EB - Genetika a molekulární biologie
Impakt faktor: 3.948, rok: 2015

Blood flukes of the genus Schistosoma cause schistosomiasis, a parasitic disease that infects over 240 million people worldwide, and for which there is a need to identify new targets for chemotherapeutic interventions. Our research is focused on Schistosoma mansoni prolyl oligopeptidase (SmPOP) from the serine peptidase family S9, which has not been investigated in detail in trematodes.
Trvalý link: http://hdl.handle.net/11104/0256550