Počet záznamů: 1  

Development of Soft Tissue Sarcomas in Ribosomal Proteins L5 and S24 Heterozygous Mice

  1. 1.
    0455741 - UMG-J 2016 RIV AU eng J - Článek v odborném periodiku
    Kazerounian, S. - Ciarlini, P.D.S.C. - Yuan, D. - Ghazvinian, R. - Alberich-Jorda, Meritxell - Joshi, M. - Zhang, H. - Beggs, A.H. - Gazda, H.T.
    Development of Soft Tissue Sarcomas in Ribosomal Proteins L5 and S24 Heterozygous Mice.
    Journal of Cancer. Roč. 7, č. 1 (2016), s. 32-36. ISSN 1837-9664
    Grant CEP: GA MŠk LK21307
    Institucionální podpora: RVO:68378050
    Klíčová slova: Ribosomal proteins RPL5 and RPS24 * Diamond-Blackfan anemia * Soft tissue sarcoma
    Kód oboru RIV: EB - Genetika a molekulární biologie
    Impakt faktor: 2.916, rok: 2016

    Diamond-Blackfan anemia (DBA) is an inherited bone marrow failure syndrome associated with ribosomal protein (RP) gene mutations. Recent studies have also demonstrated an increased risk of cancer predisposition among DBA patients. In this study, we report the formation of soft tissue sarcoma in the Rpl5 and Rps24 heterozygous mice. Our observation suggests that even though one wild-type allele of the Rpl5 or Rps24 gene prevents anemia in these mice, it still predisposes them to cancer development.
    Trvalý link: http://hdl.handle.net/11104/0256358