Počet záznamů: 1  

Targeted modulation of alternative splicing by TALE-directed chromatin editing

  1. 1.
    0454301 - UMG-J 2016 RIV GB eng A - Abstrakt
    Bieberstein, Nicole - Staněk, David
    Targeted modulation of alternative splicing by TALE-directed chromatin editing.
    FEBS Journal. Roč. 282, SI (2015), s. 210-210. ISSN 1742-464X.
    [40th Congress of the Federation-of-European-Biochemical-Societies (FEBS) - The Biochemical Basis of Life. 04.07.2015-09.07.2015, Berlín]
    Grant CEP: GA ČR(CZ) GBP305/12/G034
    Institucionální podpora: RVO:68378050
    Klíčová slova: histone methylation * pre-mRNA splicing * TALEN
    Kód oboru RIV: EB - Genetika a molekulární biologie

    To reveal how local chromatin modulates the splicing outcome we developed a new method based on Transcription Activator-Like Effector Nuclease (TALEN) technology. We replaced the nuclease domain with chromatin modifying domain and tested how TALE based targeting of histone methyltransferases and a demethylase influences splicing of the targeted exon.
    Trvalý link: http://hdl.handle.net/11104/0255078