Počet záznamů: 1  

Development of Small-Molecule Antivirals for Ebola

  1. 1. 0450477 - UOCHB-X 2016 RIV US eng J - Článek v odborném periodiku
    Janeba, Zlatko
    Development of Small-Molecule Antivirals for Ebola.
    Medicinal Research Reviews. Roč. 35, č. 6 (2015), s. 1175-1194. ISSN 0198-6325
    Institucionální podpora: RVO:61388963
    Klíčová slova: antiviral * filovirus * Ebola virus * Marburg virus * hemorrhagic fever
    Kód oboru RIV: CC - Organická chemie
    Impakt faktor: 9.135, rok: 2015

    Ebola hemorrhagic fever is a deadly disease caused by infection with one of the Ebola virus species. Although a significant progress has recently been made in understanding of Ebola virus biology and pathogenesis, development of effective anti-Ebola treatments has not been very productive, compared to other areas of antiviral research (e.g., HIV and HCV infections). No approved vaccine or medicine is available for Ebola but several are currently under development. This review summarises attempts in identification, evaluation, and development of small-molecule candidates for treatment of Ebola viral disease, including the most promising experimental drugs brincidofovir (CMX001), BCX4430, and favipiravir (T-705).
    Trvalý link: http://hdl.handle.net/11104/0251768