Počet záznamů: 1  

Orally active epoxyeicosatrienoic acid analog does not exhibit antihypertensive and reno- or cardioprotective actions in two-kidney, one-clip Goldblatt hypertensive rats

  1. 1.
    0448316 - FGÚ 2016 RIV US eng J - Článek v odborném periodiku
    Alánová, Petra - Husková, Z. - Kopkan, L. - Sporková, A. - Jíchová, Š. - Neckář, Jan - Imig, J. D. - Klevstig, Martina - Kolář, František - Reddy, N. R. - Falck, J. R. - Sadowski, J. - Nishiyama, A. - Kramer, H. J. - Melenovský, V. - Červenková, L. - Kujal, P. - Vernerová, Z. - Červenka, L.
    Orally active epoxyeicosatrienoic acid analog does not exhibit antihypertensive and reno- or cardioprotective actions in two-kidney, one-clip Goldblatt hypertensive rats.
    Vascular Pharmacology. Roč. 73, Oct 2015 (2015), s. 45-56. ISSN 1537-1891
    Grant CEP: GA ČR(CZ) GA15-08066S; GA ČR(CZ) GAP303/12/1162
    Institucionální podpora: RVO:67985823
    Klíčová slova: renovascular hypertension * myocardial ischemia/reperfusion injury * 14,15-epoxyeicosatrienoic acid analog * renin-angiotensin system
    Kód oboru RIV: FA - Kardiovaskulární nemoci vč. kardiochirurgie
    Impakt faktor: 2.500, rok: 2015

    We examined the effects of a novel orally active 14,15-epoxyeicosatrienoic acid analog (EET-A) on blood pressure (BP) and myocardial infarct size (IS) in two-kidney, one-clip (2K1C) Goldblatt hypertensive rats during sustained phase of hypertension. Our findings suggest that during the phase of sustained hypertension 2K1C Goldblatt hypertensive rats exhibit increased cardiac tolerance to I/R injury as compared with normotensive controls, and that in this animal model of human renovascular hypertension short-term treatment with EET-A does not induce any antihypertensive and cardioprotective actions
    Trvalý link: http://hdl.handle.net/11104/0250053