Pathogenetic Mechanisms of Neurogenic Pulmonary Edema

0446969 - FGÚ 2016 RIV US eng J - Článek v odborném periodiku
Šedý, Jiří - Kuneš, Jaroslav - Zicha, Josef
Pathogenetic Mechanisms of Neurogenic Pulmonary Edema.
Journal of Neurotrauma. Roč. 32, č. 15 (2015), s. 1135-1145. ISSN 0897-7151. E-ISSN 1557-9042
Grant CEP: GA ČR(CZ) GAP304/12/0259
Institucionální podpora: RVO:67985823
Klíčová slova: baroreflex-induced bradycardia * blood pressure rise * blood volume redistribution * neurogenic pulmonary edema * spinal cord injury * sympathetic nervous system
Kód oboru RIV: ED - Fyziologie
Impakt faktor: 4.377, rok: 2015

Neurogenic pulmonary edema (NPE) is a life-threatening complication of central nervous system (CNS) injuries. NPE may develop as a result of activation of specific CNS trigger zones located in the brainstem, leading to a rapid sympathetic discharge, rise in systemic blood pressure, baroreflex-induced bradycardia, and enhanced venous return resulting in pulmonary vascular congestion characterized by interstitial edema, intra-alveolar accumulation of transudate, and intra-alveolar hemorrhages. Degree of anesthesia is a crucial determinant for the extent of NPE development in experimental models because of its influence on sympathetic nervous system activity. Attenuation of sympathetic nerve activity or abolition of reflex bradycardia completely prevent NPE development in our experimental model
Trvalý link: http://hdl.handle.net/11104/0248945