Mitochondria in Cancer: Why Mitochondria Are a Good Target for Cancer Therapy

0444484 - BTÚ 2016 RIV US eng J - Článek v odborném periodiku
Dong, L.F. - Neužil, Jiří
Mitochondria in Cancer: Why Mitochondria Are a Good Target for Cancer Therapy.
Progress in Molecular Biology and Translational Science. Roč. 2014, č. 127 (2014), s. 211-227. ISSN 1877-1173
Institucionální podpora: RVO:86652036
Klíčová slova: ALPHA-TOCOPHERYL SUCCINATE * RESPIRATORY COMPLEX-II * DNA MUTATIONS
Kód oboru RIV: EB - Genetika a molekulární biologie
Impakt faktor: 3.488, rok: 2014

Cancer can be characterized as a state of multifaceted cellular deregulation including control of proliferation and bioenergetics. The latter involves in particular mitochondria, the site of the generation of ATP, essential for the proper cellular function (including proliferation). Mitochondria also contain a variety of proteins that are necessary for the induction/promotion, as well as for the prevention of cell death. Therefore, mitochondria are pivotal in deciding the fate of a cell. In cancer, mitochondria are dysfunctional, which was observed as early as in the 1930s by Otto Warburg. Due to the central role of mitochondria, these organelles, endowed with its own DNA, are a focus of research as possible "culprits" for the malignancy of cancer cells (or at least contributing to this phenotype) and, importantly, as emerging targets for anticancer therapy.
Trvalý link: http://hdl.handle.net/11104/0248815