Počet záznamů: 1  

Endogenous lentivirus in Malayan colugo (Galeopterus variegatus), a close relative of primates

  1. 1.
    0441030 - ÚMG 2015 RIV GB eng J - Článek v odborném periodiku
    Hron, Tomáš - Fábryová, Helena - Pačes, Jan - Elleder, Daniel
    Endogenous lentivirus in Malayan colugo (Galeopterus variegatus), a close relative of primates.
    Retrovirology. Roč. 11, č. 84 (2014). E-ISSN 1742-4690
    Grant CEP: GA MŠMT(CZ) LK11215
    Grant ostatní: GA MŠk(CZ) LM2010005
    Institucionální podpora: RVO:68378050
    Klíčová slova: Endogenous lentiviruses * Dermoptera * Paleovirology
    Kód oboru RIV: EB - Genetika a molekulární biologie
    Impakt faktor: 4.185, rok: 2014

    Background: A significant fraction of mammalian genomes is composed of endogenous retroviral (ERV) sequences that are formed by germline infiltration of various retroviruses. In contrast to other retroviral genera, lentiviruses only rarely form ERV copies. We performed a computational search aimed at identification of novel endogenous lentiviruses in vertebrate genomes.Findings: Using the in silico strategy, we have screened 104 publicly available vertebrate genomes for the presence of endogenous lentivirus sequences. In addition to the previously described cases, the search revealed the presence of endogenous lentivirus in the genome of Malayan colugo (Galeopterus variegatus). At least three complete copies of this virus, denoted ELVgv, were detected in the colugo genome, and approximately one hundred solo LTR sequences. The assembled consensus sequence of ELVgv had typical lentivirus genome organization including three predicted accessory genes. Phylogenetic analysis placed this virus as a distinct subgroup within the lentivirus genus. The time of insertion into the dermopteran lineage was estimated to be more than thirteen million years ago.Conclusions: We report the discovery of the first endogenous lentivirus in the mammalian order Dermoptera, which is a taxon close to the Primates. Lentiviruses have infiltrated the mammalian germline several times across millions of years. The colugo virus described here represents possibly the oldest documented endogenization event and its discovery can lead to new insights into lentivirus evolution. This is also the first report of an endogenous lentivirus in an Asian mammal, indicating a long-term presence of this retrovirus family in Asian continent.
    Trvalý link: http://hdl.handle.net/11104/0244120

    Název souboruStaženoVelikostKomentářVerzePřístup
    0441030.pdf4701.7 KBVydavatelský postprintvyžádat
    0441030.pdf7701.7 KBVydavatelský postprintvyžádat
Počet záznamů: 1  

  Tyto stránky využívají soubory cookies, které usnadňují jejich prohlížení. Další informace o tom jak používáme cookies.